FAT Tumor Suppressor Homolog 3 (FAT3)

The 4,555-amino acid rat protein has an N-terminal signal peptide, followed by 34 cadherin domains, an EGF -like motif, a laminin A-G domain, 3 additional EGF-like motifs, a transmembrane domain, and cytoplasmic C-terminal tail. Immunofluorescence staining detected predominant Fat3 expression in fetal rat central nervous system.

The deduced 4,557-amino acid protein contains 33 cadherin repeats, a laminin G domain, and 2 EGF domains in its extracellular region, followed by a transmembrane domain and a cytoplasmic C-terminal domain containing a PDZ-binding motif. In silico analysis detected FAT3 mRNAs in embryonic stem cells, primitive neuroectoderm, fetal brain, infant brain, and adult neural tissues and prostate.