FGFR1 Oncogene Partner 2 (FGFR1OP2)

Microarray data indicated that FGFR1OP2 is expressed in diverse tissues, including bone marrow, spleen, and thymus. FGFR1OP2 is highly conserved in evolution, sharing 99% and 98% amino acid identity with its mouse and rat homologs, respectively. FGFR1OP2 homologs are also present in frog and insect genomes.FGFR1OP2-FGFR1 has the first 2 coiled-coil domains of FGFR1OP2 fused to the entire tyrosine kinase domain and part of the juxtamembrane region of FGFR1. Reciprocal FGFR1-FGFR1OP2 transcripts were not detected. Since the direction of FGFR1OP2 transcription is in the opposite orientation to the direction of FGFR1 transcription, an inversion must have taken place in the formation of the chimeric gene.