FXYD Domain Containing Ion Transport Regulator 6 (FXYD6)

The FXYD proteins share homology for a single transmembrane domain. Each FXYD protein is expressed in a tissue-specific manner and functions by altering the kinetic activity of Na,K-ATPase.

FXYD6 encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. FXYD6, is novel and has not been characterized as a protein. The expression of FXYD6 in humans is primarily in the brain, with highest level of expression found in the prefrontal cortex, amygdala, hypothalamus, and occipital lobe.FXYD6 are found in all tissues except blood, suggesting wide but not ubiquitous expression.The deduced FXYD6 protein contains 95 amino acids.