Family With Sequence Similarity 178, Member A (FAM178A)

Nikali et al. (2002) isolated C10ORF6 cDNA by database analysis of expressed sequences in the chromosome 10q24 region. The deduced 1,173-amino acid protein has a predicted molecular weight of 132 kD and contains an SH3 domain. PCR analysis detected ubiquitous expression in human fetal tissues with highest levels in skeletal muscle, moderate levels in lung, kidney, spleen, and thymus, and lowest levels in brain, liver and heart. Northern blot analysis detected a 7.5-kb transcript in all adult human tissues examined.

Nikali et al. (2002) determined that the C10ORF6 gene contains 20 exons spanning 53 kb.By sequence analysis, Nikali et al. (2002) mapped the C10ORF6 gene to chromosome 10q24.