Dermal Papilla Derived Protein 5 (DERP5)

C10ORF97 is a member of the caspase-associated recruitment domain (CARD) family of proteins that play a role in apoptosis.The deduced 445-amino acid protein has a calculated molecular mass of 49.7 kD and contains a nuclear receptor-binding motif, a caspase-associated recruitment domain, 2 EF-hand calcium-binding motifs, and an estimated 42% alpha-helix content. C10ORF97 also contains 17 potential phosphorylation sites and 4 N-myristoylation sites. C10ORF97 shares 95.5% amino acid similarity with its mouse ortholog and shares similarity over the CARD domain with many apoptosis proteins including APAF1, RAIDD (CRADD), and CASP1 . Northern blot analysis of human tissues detected strong expression in heart, skeletal muscle, and kidney, with weak expression in liver and brain.