Family With Sequence Similarity 20, Member B (FAM20B)

Using representational difference analysis to identify genes that are differentially expressed during experimentally induced myeloid differentiation in the mouse EML hematopoietic stem cell line, By database analysis with the mouse Fam20a sequence as query, Nalbant et al. (2005) identified a family of genes with related sequence that included 2 additional members in mammals, FAM20B and FAM20C . The 3 deduced proteins are highly conserved in human, mouse, and rat. All contain a conserved putative signal sequence and a conserved C-terminal sequence. The deduced human FAM20B protein contains 459 amino acids. Expression analysis showed that, like FAM20A, FAM20B and FAM20C are expressed during hematopoiesis.The International Radiation Hybrid Mapping Consortium mapped the FAM20B gene to chromosome 1 .