Striatin Interacting Protein 1 (STRIP1)

The serine/threonine protein phosphatases are targeted to specific subcellular locations and substrates in part via interactions with a wide variety of regulatory proteins. Understanding these interactions is thus critical to understanding phosphatase function. This approach recapitulated the assembly of the PP2A catalytic subunit into many different trimeric complexes, but also revealed several new protein-protein interactions. referred to as the STRIPAK complex. STRIPAK contains the PP2A catalytic (PP2Ac) and scaffolding (PP2A A) subunits, the striatins (PP2A regulatory B''' subunits), the striatin-associated protein Mob3, the novel proteins STRIP1 and STRIP2 (formerly FAM40A and FAM40B), the cerebral cavernous malformation 3 (CCM3) protein, and members of the Germinal Center Kinase III family of Ste20 kinases.