Family With Sequence Similarity 53, Member C (FAM53C)

Lai et al. (2000) identified C5ORF6 within a region of chromosome 5q frequently deleted in malignant myelomas. The deduced 392-amino acid protein has a calculated molecular mass of about 43 kD. The N terminus contains a proline-rich sequence that includes 3 potential SH3 domain-binding sites. Northern blot analysis detected a 4.3-kb transcript in all lymphoid tissues examined. C5ORF6 was also expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas.

By genomic sequence analysis, Lai et al. (2000) determined that the C4ORF6 gene contains 5 exons and spans about 11 kb.By genomic sequence analysis, Lai et al. (2000) mapped the C5ORF6 gene to chromosome 5q31.