Family With Sequence Similarity 70, Member B (FAM70B)

Family With Sequence Similarity 70, Member B (FAM70B)
FAM70B is a 326 amino acid membrane protein that belongs to the FAM70 family. FAM70B contains around 114 million base pairs and encodes roughly 400 genes. Key tumor suppressor genes on chromosome 13 include the breast cancer susceptibility gene, BRCA2, and the RB1 gene. RB1 encodes a crucial tumor suppressor protein which, when defective, leads to malignant growth in the retina and has been implicated in a variety of other cancers. The gene SLITRK1, which is associated with Tourette syndrome, is on chromosome 13. As with most chromosomes, polysomy of part or all of chromosome 13 is deleterious to development and decreases the odds of survival. Trisomy 13, also known as Patau syndrome, is quite deadly and the few who survive past one year suffer from permanent neurologic defects, difficulty eating and vulnerability to serious respiratory infections.

Organism species: Homo sapiens (Human)

Organism species: Mus musculus (Mouse)