Family With Sequence Similarity 92, Member A1 (FAM92A1)

FAM92A1 was ubiquitously expressed,and homology analysis in NCBI GENE database showed that the FAM92A1 was highly conservative.The FAM92A1 protein belonged to a conserved domain of DUF1208,which contain a coiled coil domain and several phosphorylation sites.Compared Human to Chimpanzee, Mouse, Rats, Gallus gallus, X. laevis, Zebrafish, Drosophila melanogaster, the amino acid similarity of FAM92A1 protein is 91%, 84%, 82%, 74%, 67%, 65%, 26%, respectively.There was no signal peptide and trans membrane structure in FAM92A1 protein.The subcellular location analysis of FAM92A1 showed it was a nuclear protein.Conclusion According to the preliminary inference,FAM92A1 is a kind of regulatory protein in nucleus,which may play an important role in the proliferation and differentiation in development.