Far Upstream Element Binding Protein 2 (FUBP2)

The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization. The pre-mRNA of the protooncogene SRC contains an 18-nucleotide exon, N1, that is spliced into the mRNA in neuronal cells but is excluded in nonneuronal cells. N1 exon inclusion in neurons is under the positive control of an intronic regulatory sequence called the downstream control sequence (DCS).The predicted 711-amino acid protein contains a proline/glycine-rich N terminus and a C-terminal domain that is rich in proline, glycine, alanine, and glutamine. The central region contains 4 tandemly repeated KH domains, leading the authors to rename the protein 'KH-type splicing regulatory protein' (KSRP).