Farnesylated Protein Converting Enzyme 2 (FACE2)

FACE2encodes an integral membrane protein which is classified as a member of the metalloproteinase family. This enzyme is thought to function in the maintenance and processing of CAAX-type prenylated proteins.

RCE1 encodes a deduced 329-amino acid protein that shares 42% identity over 105 amino acids with the yeast protein and contains several predicted transmembrane domains. RCE1 transcript in heart, brain, placenta, lung, liver, muscle, kidney, and pancreas. A weaker 2.4-kb transcript was also detected in some tissues. Northern blot analysis of mouse tissues revealed broad expression and multiple transcript sizes.The partial recombinant human RCE1 clone used all forms of Ras as substrates, suggesting that the enzyme can use a broad range of CAAX-type prenyl protein substrates.