Fas Apoptotic Inhibitory Molecule (FAIM)

FAIM belongs to the FAIM1 family. Plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement in B cells. Apoptosis, or programmed cell death, is used in a number of biologic processes from modeling the embryo and regulating the immune system to tumor regression. Conversely, dysfunction of this system has been implicated in oncogenesis, development of autoimmunity, and degenerative diseases. Intense study of this process identified membrane-bound receptors and their cognate ligands that together begin the program that ultimately leads to cell death. The FAS receptor, also called CD95 or Apo1, is one such receptor, of which the gene is designated TNFRSF6 to indicate that it is a member of the tumor necrosis factor (TNF) receptor superfamily.