Fc Fragment Of IgE, High Affinity I, Receptor For Gamma Polypeptide (FceR1g)

The high-affinity IgE receptor, 1 of the key molecules involved in allergic reactions, is a tetramer of 1 alpha , 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors.

cotransduction of KIR2DL4 with FCER1G promoted cell surface expression of KIR2DL4 and Ca(2+) mobilization, whereas cotransduction of KIR2DL4 with DAP10, DAP12 (TYROBP), or TCRZ (CD247) did not. Coimmunoprecipitation analysis demonstrated physical association of FCER1G with KIR2DL4. Cytotoxicity was enhanced in resting NK cells by engagement of NKp44 (NCR2), which is associated with DAP12, whereas cytotoxicity was augmented in activated NK cells by stimulating NKp46 (NCR1) or KIR2DL4, which are associated with FCER1G.