Fetal And Adult Testis Expressed Protein 1 (FATE1)

FATE1 encodes a cancer-testis antigen that is highly expressed in hepatocellular carcinomas and other tumors and weakly expressed in normal tissues except testis. The protein is strongly expressed in spermatogonia, primary spermatocytes, and Sertoli cells in seminiferous tubules. This protein may have a role in the control of early testicular differentiation and cell proliferation.

The 5-prime flanking region contains a TATA box, a putative steroidogenic factor-1 (SF1)-binding site, and 3 elements similar to Wilms tumor antigen-1-binding site consensus sequences.FATE is a soluble polypeptide with a single C-terminal transmembrane helix. expression in lung, heart, kidney, adrenal gland, and whole brain.