Fibroblast Growth Factor Binding Protein 1 (FGFBP1)

FGFBP1 binds to both acidic (FGF1) and basic (FGF2;) fibroblast growth factors in a reversible manner. It also binds to perlecan (HSPG2).HBP17 interacts with both FGF1 and FGF2. Like heparin, HBP17 protected both FGF molecules from acid inactivation. HBP17 inhibited the mitogenic activity of FGF1 more efficiently than that of FGF2 in the absence of heparin, and it blocked binding to a liver cell line.

The predicted 234-amino acid secreted protein contains a signal sequence and a potential N-linked glycosylation site. Expression was not detected in any other cell lines tested, including nontumorigenic epidermoid cell lines. Immunoblot analysis detected a 17-kD protein that comigrated with FGF2.