Fibronectin Type III And SPRY Domain Containing Protein 1 (FSD1)

FSD1 encodes a centrosome associated protein that is characterized by an N-terminal coiled-coil region downstream of B-box (BBC) domain, a central fibronectin type III domain, and a C-terminal repeats in splA and RyR (SPRY) domain. The encoded protein associates with a subset of microtubules and may be involved in the stability and organization of microtubules during cytokinesis.

FSD1 shares 92% amino acid identity with mouse Fsd1 and significant similarity with its bovine and porcine paralogs. It also shares significant similarity with FSD1NL. Northern blot analysis of several human tissues detected abundant expression of a major 1.8- to 2.0-kb transcript and minor 3.0- and 3.5-kb transcripts in brain only.