Fidgetin Like Protein 1 (FIGNL1)

The FIGNL1 gene was proven to be a new subfamily member of ATPases associated with diverse cellular activities. In this in vitro study, the AAA proteins inhibited osteoblast proliferation and stimulated osteoblast differentiation. FIGNL1 may play some regulatory role in osteoblastogenesis.

FIGNL1 encodes a new subfamily member of ATPases associated with diverse cellular activities. Although the FIGNL1 protein localizes to both the nucleus and cytoplasm, the function of FIGNL1 remains unknown. Overexpression of FIGNL1 reduced the proliferation of MC3T3-E1 and calvarial cells, more than the mock transfected control cells did. FIGNL1, a subfamily member of the AAA family of proteins, might play some regulatory role in osteoblast proliferation and differentiation.