Fizzy/Cell Division Cycle 20 Related Protein 1 (FZR1)
CDH1; CDC20C; FZR; FZR2; HCDH; HCDH1; CDC20-like protein 1; Cdh1/Hct1 homolog
Activation of the anaphase-promoting complex (APC) is required for anaphase initiation and for exit from mitosis. Fang et al. (1998) showed that APC is activated during mitosis and G1 by 2 regulatory factors, CDC20 and HCDH1. These proteins directly bind to APC and activate its cyclin ubiquitination activity. CDC20 confers a strict destruction box (D box) dependence on APC, while HCDH1 shows a much more relaxed specificity for the D box. HCDH1 contains WD40 repeats and is more closely related to yeast CDH1/HCT1 and Xenopus and Drosophila fzr, with which it shows 36%, 96%, and 69% sequence identity, respectively. In HeLa cells, the HCDH1 protein levels remain constant during the cell cycle and may target specific substrates lacking the D box in G1, such as polo-like kinase, for ubiquitination.
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
- Customized Service n/a Recombinant Fizzy/Cell Division Cycle 20 Related Protein 1 (FZR1) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Fizzy/Cell Division Cycle 20 Related Protein 1 (FZR1) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Fizzy/Cell Division Cycle 20 Related Protein 1 (FZR1) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Fizzy/Cell Division Cycle 20 Related Protein 1 (FZR1) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Fizzy/Cell Division Cycle 20 Related Protein 1 (FZR1) ELISA Kit Customized Service Offer
Organism species: Rattus norvegicus (Rat)
- Customized Service n/a Recombinant Fizzy/Cell Division Cycle 20 Related Protein 1 (FZR1) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Fizzy/Cell Division Cycle 20 Related Protein 1 (FZR1) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Fizzy/Cell Division Cycle 20 Related Protein 1 (FZR1) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Fizzy/Cell Division Cycle 20 Related Protein 1 (FZR1) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Fizzy/Cell Division Cycle 20 Related Protein 1 (FZR1) ELISA Kit Customized Service Offer