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ITEM PROTEIN ANTIBODY ASSAY KIT CELL
Folliculin (FLCN)
BHD; FLCL
Using coimmunoprecipitation of FNIP1 and FLCN expressed in HEK293 cells and in vitro binding assays, the C-terminus of FLCN and amino acids 300 to 1166 of FNIP1 were shown to be required for optimal FLCN-FNIP1 binding. FLCN and FNIP1 colocalized to the cytoplasm in a reticular pattern. FNIP1 was phosphorylated by AMPK and its phosphorylation was inhibited in a dose-dependent manner by an AMPK inhibitor, resulting in reduced FNIP1 expression. FLCN phosphorylation was diminished by rapamycin and amino acid starvation and facilitated by FNIP1 overexpression, suggesting that FLCN phosphorylation may be regulated by mTOR and AMPK signaling. FLCN and FNIP1 may be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME
Proteins RPJ102Hu01 Recombinant Folliculin (FLCN) Customize
Antibodies MAJ102Hu21 Monoclonal Antibody to Folliculin (FLCN) Customize
PAJ102Hu01 Polyclonal Antibody to Folliculin (FLCN) Customize
PAJ102Hu71 Biotin-Linked Antibody to Folliculin (FLCN) Customize
Assay Kits SEJ102Hu ELISA Kit for Folliculin (FLCN) In Stock
SCJ102Hu CLIA Kit for Folliculin (FLCN) Customize
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME
Proteins RPJ102Mu01 Recombinant Folliculin (FLCN) Customize
Antibodies PAJ102Mu01 Polyclonal Antibody to Folliculin (FLCN) Customize
MAJ102Mu21 Monoclonal Antibody to Folliculin (FLCN) Customize
Assay Kits SEJ102Mu ELISA Kit for Folliculin (FLCN) Customize
SCJ102Mu CLIA Kit for Folliculin (FLCN) Customize
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME
Proteins RPJ102Ra01 Recombinant Folliculin (FLCN) Customize
Antibodies PAJ102Ra01 Polyclonal Antibody to Folliculin (FLCN) Customize
MAJ102Ra21 Monoclonal Antibody to Folliculin (FLCN) Customize
Assay Kits SEJ102Ra ELISA Kit for Folliculin (FLCN) Customize
SCJ102Ra CLIA Kit for Folliculin (FLCN) Customize