Forkhead Box Protein K2 (FOXK2)

Forkhead Box K2(FOXK2)contains a fork head DNA binding domain. This protein can bind to the purine-rich motifs of the HIV long terminal repeat (LTR), and to the similar purine-rich motif in the interleukin 2 (IL2) promoter. It may be involved in the regulation of viral and cellular promoter elements.

Li et al. (1991) cloned ILF from both HeLa and Jurkat cDNA libraries. Further analysis of demonstrated the existence of 2 mRNA species, both of which encode proteins containing the forkhead DNA-binding domain (Li et al., 1992).Li et al. (1991) found that ILF bound to purine-rich regulatory motifs in the HIV-1 long terminal repeat and to the interleukin-2 (IL2; 147680) promoter.