Formin Binding Protein 2 (FNBP2)

The FNBP2 has 1,095 amino acids and is 35.7% identical to C1 RHOGAP. It was predicted to be involved in cell signaling/communication. RT-PCR analysis detected low-level expression of KIAA0456 in placenta, kidney, and ovary, with little or no expression in all other tissues tested.

The centrally located RHOGAP domain in SRGAP2 is highly similar to the RHOGAP domains of SRGAP1, SRGAP3, and C1 RHOGAP. The SH3 domain in SRGAP2 is similar to those in SRGAP1, SRGAP3, C1 RHOGAP, and CSK. Northern blot analysis detected SRGAP2 transcripts of 9.5, 8.0, and 4.4 kb in all tissues tested, with the 4.4-kb transcript being the most abundant. In situ hybridization of rodent tissues showed that Srgap1 and Srgap2 are expressed in regions responsive to Slit.