Formin Homology 2 Domain Containing Protein 3 (FHOD3)

Proteins that contain formin (FMN1) homology (FH) domains, such as FHOD3, play a role in regulation of the actin cytoskeleton.The deduced full-length protein contains 1,439 amino acids and has a central FH1 domain and a C-terminal FH2 domain. FHOD3 shares 52.1% amino acid identity with FHOD1 and 43.9% amino acid identity with the Drosophila FHOD3 ortholog. In addition to the FH1 and FH2 domains, these proteins have conserved N- and C-terminal domains that the authors designated FHDHN and FHDHC, respectively.The deduced protein contains 1,199 amino acids. RT-PCR ELISA detected highest expression in heart, followed by fetal brain and adult skeletal muscle. Intermediate expression was detected in all other whole tissues and specific brain regions examined.