Four And A Half LIM Domains Protein 2 (FHL2)

FHL2 protein contains 279 amino acids and has a calculated molecular mass of about 32 kD.The gene, termed DRAL for 'down-regulated in rhabdomyosarcoma LIM protein,' encodes a 279-amino acid polypeptide with an observed mass of 32 kD. The protein sequence contains 4 complete LIM domains and the second half of a fifth LIM domain. DRAL appears to be a member of the LIM-only class of proteins, which consist primarily of LIM domains and little else. Southern blotting revealed a single-copy gene that is conserved among vertebrates. FHL2 immunoreactivity is confined almost entirely to the cell membranes. FHL2 also localized to the basal cell compartment. In undifferentiated prostate carcinoma, FHL2 was overexpressed and staining redistributed to the cytoplasm and nuclei of tumor cells.