Frizzled Homolog 2 (FZD2)

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The expression of the FZD2 gene appears to be developmentally regulated, with high levels of expression in fetal kidney and lung and in adult colon and ovary.

The full-length cDNA of FZD2 encodes a protein of 565 amino acids that shares 56% sequence identity with Drosophila fz protein. the expression of the FZD2 gene appears to be developmentally regulated, with high levels of expression in fetal kidney and lung and in adult colon and ovary. The structure of FZD2 suggests that it has a role in transmembrane signal transmission, although its precise physiologic function and associated pathways have yet to be determined.