Frizzled Homolog 5 (FZD5)

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD5 protein is believed to be the receptor for the Wnt5A ligand.

Wang et al. (1996) cloned and sequenced a large family of mammalian homologs of the Drosophila polarity gene 'frizzled'. One of these was a human gene, termed 'frizzled 5,' isolated from a retina cDNA library. Wang et al. (1996) determined that this gene encodes a polypeptide of 585 amino acids. He et al. (1997) showed that human frizzled 5 is the receptor for the Wnt5A ligand.Wang et al. (1996) used interspecific backcross analysis to map the gene to mouse chromosome 1 between the markers Ctla4 and Fn1, which is syntenic to human chromosome 2q33-q34.