Fructosamine-3-Kinase Related Protein (FN3KRP)

FN3KRP and FN3K protect proteins from nonenzymatic glycation by phosphorylating the modified amino acid. This phosphorylation destabilizes the sugar-amine linkage and leads to spontaneous decomposition.

The deduced 309-amino acid protein has a calculated molecular mass of 34.4 kD and shares 88% identity with mouse Fn3krp. Like FN3K, FN3KRP has an HGDxxxxN motif that is also found in aminoglycoside kinases. Northern blot analysis detected Fn3krp expression in all mouse tissues examined except intestinal mucosa. Highest expression was in bone marrow, brain, spleen, and kidney.FN3KRP is a ketosamine 3-kinase with a substrate specificity distinct from that of FN3K.