FtsJ Homolog 1 (FTSJ1)

FTSJ1 protein is a homolog of Escherichia coli RNA methyltransferase FtsJ/RrmJ and may play a role in the regulation of translation.

The deduced 842-amino acid protein contains a 221-amino acid N-terminal S-adenosyl-L-methionine (AdoMet)-binding domain found in AdoMet-dependent methyltransferases. The Spb1 protein localized to the nucleolus. Pintard et al. (2000) confirmed that yeast Spb1 binds AdoMet, suggesting that it is a methylase. They found that temperature-sensitive mutant alleles of Spb1 could suppress the deletion of the poly(A)-binding protein gene (Pab1). The mutant alleles were also associated with reduced 60S ribosome subunit content and abnormalities in the processing of other ribosomal subunits.