rRNA Methyltransferase 2, Mitochondrial (MRM2)

The deduced 246-amino acid protein has a calculated molecular mass of 27.4 kD and contains a methyltransferase domain. An iterative search of all available DNA sequences suggested that FTSJ2 is a member of a large and diverse family of evolutionarily conserved S-adenosylmethionine-binding proteins from bacteria to human, which contains at least 180 members.

Northern blot analysis detected a 1.7-kb transcript in most tissues, with highest expression in muscle, placenta, and heart. A 2.6-kb transcript, which may represent a splice variant, was detected in heart. Both transcripts were found in all cancer cells tested. Ching et al. (2002) localized fluorescence-tagged FTSJ2 to the nucleolus of transiently transfected HeLa cells.