FtsJ Methyltransferase Domain Containing Protein 1 (FTSJD1)

FTSJD1, Belongs to the methyltransferase superfamily. RlmE family. Adrift subfamily. adrift, a novel bnlinduced Drosophila gene, required for tracheal pathfinding into the CNS.

Adrift regulates expression of tracheal genes required for pathfinding on the segmental nerve, and FGF induction of adrift expression in migrating tracheal cells promotes the switch from the intersegmental to the segmental nerve. In adrift mutants, ganglionic branches migrate normally along the intersegmental nerve, but sporadically fail to switch to the segmental nerve and enter the CNS; they wind up meandering along the ventral epidermis instead. adrift encodes a novel nuclear protein with an evolutionarily conserved motif.