Fusion (FUS)

CHOP; ALS6; TLS; hnRNP-P2; Amyotrophic Lateral Sclerosis 6; Heterogeneous Nuclear Ribonucleoprotein P2; 75 kDa DNA-pairing protein; Translocated in liposarcoma protein
Fusion (FUS)
FUS is a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. The N-terminal end of FUS appears to be involved in transcriptional activation, while the C-terminal end is involved in protein and RNA binding. In addition recognition sites for the transcription factors AP2, GCF, Sp1 have been identified in FUS.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
Organism species: Rattus norvegicus (Rat)
  • Protein RPC260Ra01Recombinant Fusion (FUS)Customize
  • AntibodyPAC260Ra01Polyclonal Antibody to Fusion (FUS)Customize
  • AntibodyMAC260Ra21Monoclonal Antibody to Fusion (FUS)Customize
  • Assay KitSEC260RaELISA Kit for Fusion (FUS)Customize
  • Assay KitSCC260RaCLIA Kit for Fusion (FUS)Customize
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