G Antigen 1 (GAGE1)

CT4.1; Cancer/Testis Antigen Family 4,Member 1; Antigen MZ2-F

G Antigen 1 (GAGE1)
GAGE1 belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except for the testis. The sequences of the family members are highly related but differ by scattered nucleotide substitutions. The GAGE1 cDNA contains a 143-bp insertion, located in the coding sequence near the termination codon, that is absent from the other cDNAs.The antigenic peptide YRPRPRRY, which is also encoded by several other family members, is recognized by autologous cytolytic T lymphocytes.
However, the GAGE1 cDNA contains a 143-bp insertion, located in the coding sequence near the termination codon, that is absent from the other cDNAs. GAGE1 transcript in a number of melanoma cell lines derived from different patients but no GAGE1 expression in the normal tissues tested.

Organism species: Homo sapiens (Human)