G Antigen 2A (GAGE2A)

GAGE2; CT4.2; Cancer/Testis Antigen Family 4 Member 2

G Antigen 2A (GAGE2A)
Human melanoma cells express several distinct antigens that are recognized by autologous cytolytic T lymphocytes (CTLs). One class of these antigens is encoded by genes, such as MAGE1 (MAGEA1), MAGE3 (MAGEA3), and BAGE, that are expressed in a large fraction of tumors of various histologic types but are silent in normal adult tissues, except for testis. Van den Eynde et al. (1995) identified an antigen, named MZ2-F, that is present on melanoma MZ2-MEL cells and is recognized by autologous CTLs. They isolated cDNAs encoding the MZ2-F antigen and named the corresponding gene GAGE1.
GAGE2A gene is contained within a 9.5-kb GAGE repeat. The GAGE2A gene contains 5 exons spanning about 6.3 kb and has a LINE insertion. GAGE2A gene to a GAGE gene cluster on chromosome Xp11.23.

Organism species: Homo sapiens (Human)