G Antigen 2B (GAGE2B)
CT4.2; GAGE2C; Cancer/testis antigen 4.2
GAGE cancer/testis antigens, including GAGE2B, are frequently expressed in many different types of cancer, whereas their expression in normal tissues is limited to the germ cells of the immune-privileged organs, testis and ovary.The promoters, which are highly conserved within 1.4- to 1.5-kb of the transcription initiation site, are GC-rich and have no TATA boxes. GAGE transcripts are found only in primates.
Gjerstorff and Ditzel (2008) stated that the GAGE2B gene is contained within a 9.5-kb GAGE repeat. The GAGE2B gene contains 5 exons spanning about 6.3 kb and has a LINE insertion.By genomic sequence analysis, Gjerstorff and Ditzel (2008) mapped the GAGE2B gene to a GAGE gene cluster on chromosome Xp11.23.
Organism species: Homo sapiens (Human)
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