G Protein Alpha 14 (GNa14)

GNa14 encodes a member of the guanine nucleotide-binding, or G protein family. G proteins are heterotrimers consisting of alpha, beta and gamma subunits. The encoded protein is a member of the alpha family of G proteins, more specifically the alpha q subfamily of G proteins. The encoded protein may play a role in pertussis-toxin resistant activation of phospholipase C-beta and its downstream effectors.

Using a PCR-based strategy with primers from the mouse G-alpha-14 gene, they cloned a full-length human G-alpha-14 (GNA14) cDNA from the contig. GNA14, which contains 7 exons, encodes a predicted 355-amino acid protein that is 98% and 99% identical to the mouse and bovine proteins, respectively.