G Protein Coupled Receptor 115 (GPR115)

GPR115 is a member of the LN-TM7 family of adhesion-type 7-transmembrane G-protein coupled receptors (GPCR) with long extracellular N-termini. The ECD contains a highly N-glycosylated stalk predicted to function in adhesion, followed by a cysteine-rich GPCR proteolytic cleavage site (GPS).
Phylogenetic analysis shows that these are additional members of a family of GPCRs with long N-termini, previously termed EGF-7TM, LNB-7TM, B2 or LN-7TM. Five of the receptors form their own phylogenetic cluster, while three others form a cluster with the previously reported HE6 and GPR56 (TM7XN1). All the receptors have a GPS domain in their N-terminus and long Ser/Thr-rich regions forming mucin-like stalks