G Protein Coupled Receptor 132 (GPR132)

GPR132 encodes a subfamily member of the G-protein couple receptor (GPCR) superfamily. The encoded protein is a high-affinity receptor for lysophosphatidylcholine (LPC), a major phospholipid component of oxidized low density lipoprotein. This protein may react to LPC levels at sites of inflammation to limit the expansion of tissue-infiltrating cells. A similar protein in mouse is involved in cell cycle progression.

Sequence analysis predicted that human G2A is a 380-amino acid, 7-membrane-spanning G protein-coupled receptor (GPCR) that is 70% identical to the mouse protein. It contains an N-linked glycosylation site and a putative N-terminal destruction box, which serves as a recognition motif for ubiquitin conjugation, in the first transmembrane domain.