G Protein Coupled Receptor 180 (GPR180)

GPR180 encodes a protein that is a member of the G protein-coupled receptor superfamily. This protein is produced predominantly in vascular smooth muscle cells and may play an important role in the regulation of vascular remodeling.

The deduced 440-amino acid protein, which is produced predominantly in vascular smooth muscle cells, contains an N-terminal signal sequence, 7 transmembrane regions, and a signature motif found in members of the rhodopsin-like G protein-coupled receptor superfamily. The 3-prime untranslated region contains 3 putative polyadenylation sites. Northern blot analysis detected major transcripts of 1.9 and 3.8 kb that were differentially expressed in most tissues examined.The first methionine codon of the open reading frame is located in exon 1; the termination codon and poly-A signal are in the last exon.