G Protein Coupled Receptor 33 (GPR33)

GPR33 is related to chemokine and chemoattractant receptors that control leukocyte chemotaxis. The most common GPR33 allele in humans contains a premature stop codon.An examination of genomic DNA from 1,217 humans representing all major linguistic groups revealed that the predominant human GPR33 allele has a stop at position 140. However, an intact allele encoding the full-length receptor with an arginine at position 140 was found at a frequency of 2.1%. RT-PCR detected expression of mouse Gpr33, which encodes the full-length receptor, predominantly in lung, spleen, and testis, as well as in a macrophage cell line. In human tissues, GPR33 was expressed in spleen, lung, heart, liver, kidney, pancreas, thymus, gonads, and leukocytes.