G Protein Coupled Receptor 61 (GPR61)

GPR61 belongs to the G-protein coupled receptor 1 family. G protein-coupled receptors contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. The protein encoded by this gene is most closely related to biogenic amine receptors.

GPR61 contains 7 putative transmembrane domains, a potential N-glycosylation site, cysteine residues that may form a disulfide bridge, and several putative protein kinase sites. It also contains a conserved glu-arg-tyr sequence shared with other GPCRs. The highest sequence similarity (28-31%) was found with biogenic amine GPCRs, i.e., serotonin, histamine, adrenergic, and dopamine GPCRs.