G Protein Coupled Receptor 63 (GPR63)

The deduced 419-amino acid protein shares 57% identity with Xenopus PSP24 and 92% identity with the mouse homolog.Primers to the intronless sequence were synthesized, and GPR63 cDNA was amplified by PCR and cloned. The 6.0-kb mouse transcript was expressed almost exclusively in brain. In situ hybridization of mouse brain sections revealed expression in neuronal cells such as olfactory mitral cells, cortical neurons, hippocampal pyramidal cells, and Purkinje cells in the cerebellum.

Xenopus PSP24 was originally identified as a lysophosphatidic acid receptor (LPA). Functional analysis of mouse Gpr63 transfected into a rat hepatoma cell line suggested that the mouse protein does not function as an LPA receptor.