G Protein Coupled Receptor 87 (GPR87)

G protein-coupled receptors play a role in cell communication. They are characterized by an extracellular N terminus, 7 transmembrane regions, and an intracellular C terminus.GPR87 is 89% identical to the mouse protein, lacks a leader peptide but possesses a C-terminal PDZ domain-binding site. Northern blot analysis revealed expression of a 1.6-kb GPR87 transcript in placenta, with weaker expression in thymus.The deduced 358-amino acid protein shares highest identity (51-62%) in the transmembrane regions with the UDP-glucose receptor, the platelet ADP receptor, P2Y12, and GPR86 . Northern blot analysis detected a 1.8-kb transcript at high levels in prostate and at lower levels in uterus and testis. Little expression was detected in thymus, colon, small intestine, and peripheral blood leukocytes.