G Protein Coupled Receptor 98 (GPR98)

GPR98 encodes a member of the G-protein coupled receptor superfamily. The protein binds calcium and is expressed in the central nervous system. It is also known as very large G-protein coupled receptor 1 because it is 6300 residues long. It contains a C-terminal 7-transmembrane receptor domain, whereas the large N-terminal segment (5900 residues) includes 35 calcium binding Calx-beta domains, and 6 EAR domains.

Sequence analysis predicted that the 1,967-amino acid VLGR1 protein contains an N-terminal signal peptide, 7 putative Na(+)/Ca(2+) exchangers, 21 N-linked glycosylation sites, the TM region, and a C-terminal domain with a palmitoylation site and multiple potential serine phosphorylation sites.