G Protein Coupled Receptor, Family C, Group 5, Member B (GPRC5B)

GPRC5B is a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The specific function of this protein is unknown; however, this protein may mediate the cellular effects of retinoic acid on the G protein signal transduction cascade.

The GPRC5B protein contains 7 predicted transmembrane helices and conserved cysteines characteristic of GPCRs. It also contains a predicted signal peptide and a potential N-glycosylation site. GPRC5B transcripts at highest levels in brain, with most abundant expression in corpus callosum, caudate nucleus, putamen, substantia nigra, thalamus, hippocampus, and spinal cord.