G Protein Gamma 3 (GNg3)

G proteins are heterotrimers of alpha, beta, and gamma subunits. Gamma subunits, such as GNG3, contribute to the specificity of the hundreds of receptor signaling pathways involving G proteins.

Hurowitz et al. (2000) determined the complete coding sequence of the human GNG3 gene.Using PCR, Schwindinger et al. (2004) found that mouse Gng3 was highly expressed in brain. Lower expression was detected in all other tissues tested except liver.Hurowitz et al. (2000) determined that the coding region of the GNG3 gene contains 2 exons.Schwindinger et al. (2004) reported that the mouse Gng3 gene contains 3 exons.By radiation hybrid analysis, Hurowitz et al. (2000) mapped the GNG3 gene to chromosome 11p11. They mapped the mouse gene to chromosome 19.