G Protein Pathway Suppressor 1 (GPS1)

GPS1 is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Sequence analysis revealed that the GPS1 gene encodes a 500-amino acid polypeptide that has striking similarity to the protein encoded by the Arabidopsis FUS6/COP11 gene. The FUS6/COP11 gene product is a negative regulator of light-mediated signal transduction that is known to be essential for normal development in plants.