G Protein Alpha Transducing Activity Polypeptide 2 (GNaT2)

The 354-amino acid protein shares 97% and 83% identity, respectively, with bovine GNAT2 and human GNAT1. Northern blot analysis of human retinal and WERI-RB1 RNA revealed a major transcript of 1.7 kb.The gene has 7 initiation sites spanning 31 bp. The sequence upstream shows a TATA box consensus sequence at -29, a CCAAT box consensus sequence at -58 (reverse orientation), and a sequence (CCATAT) similar to the CCAAT box consensus at -76. The GNAT2 upstream sequence shows no significant identity with the upstream region of the human rod transducin alpha-subunit gene (GNAT1) or with the upstream regions of the color visual pigment genes, indicating that the expression of GNAT2 may be regulated differently from these other rod- and cone-specific proteins.