GM2 Ganglioside Activator (GM2A)

SAP-3; Cerebroside Sulfate Activator Protein; Sphingolipid Activator Protein 3
GM2 Ganglioside Activator (GM2A)
GM2A is a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme β-hexosaminidase A. β-hexosaminidase A, together with GM2 ganglioside activator, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines.
GM2A is a lipid transfer protein that stimulates the enzymatic processing of gangliosides, and also T-cell activation through lipid presentation. This protein binds molecules of ganglioside GM2, extracts them from membranes, and presents them to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3.It was identified as a member of ML domain family of proteins involved in innate immunity and lipid metabolism in the SMART database.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
  • Protein RPL122Mu01Recombinant GM2 Ganglioside Activator (GM2A)Customize
  • AntibodyPAL122Mu01Polyclonal Antibody to GM2 Ganglioside Activator (GM2A)Customize
  • AntibodyMAL122Mu21Monoclonal Antibody to GM2 Ganglioside Activator (GM2A)Customize
  • Assay KitSEL122MuELISA Kit for GM2 Ganglioside Activator (GM2A)Customize
  • Assay KitSCL122MuCLIA Kit for GM2 Ganglioside Activator (GM2A)Customize
Organism species: Rattus norvegicus (Rat)
  • Protein RPL122Ra01Recombinant GM2 Ganglioside Activator (GM2A)Customize
  • AntibodyPAL122Ra01Polyclonal Antibody to GM2 Ganglioside Activator (GM2A)Customize
  • AntibodyMAL122Ra21Monoclonal Antibody to GM2 Ganglioside Activator (GM2A)Customize
  • Assay KitSEL122RaELISA Kit for GM2 Ganglioside Activator (GM2A)Customize
  • Assay KitSCL122RaCLIA Kit for GM2 Ganglioside Activator (GM2A)Customize
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