Myocardial Zonula Adherens Protein (MYZAP)

Gcom1 is part of a complex transcript unit that includes the gene for glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A (GRINL1A). Transcription of this gene occurs at an upstream promoter, with two different groups of alternatively spliced variants: Gup for GRINL1A upstream transcripts and Gcom for GRINL1A combined transcripts. Sequencing of genomic DNA and cloned transcripts from the 200-kb human GRINL1A gene on chromosome 15 revealed a complex gene structure comprising at least 28 exons. In one gene model, transcription begins at exon 1 and ends at exon 15b. Another gene model begins transcription at exon 20 and terminates at exon 23, 24, or 28. In a third gene model, transcription begins at exon 1 and ends at exon 23, thus conjoining two apparently discrete genes into a third combined gene.