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ITEM PROTEIN ANTIBODY ASSAY KIT CELL
GS Homeobox Protein 2 (GSX2)
Gsh2
The ETV6 gene is a frequent target of chromosomal translocations in both myeloid and lymphoid leukemias. At present, more than 40 distinct translocations have been cytogenetically described, of which 13 have now also been characterized at the molecular level. The homeobox gene GSH2 at 4q11-q12 and the IL-3/CSF2 locus at 5q31 were found to be located close to the respective breakpoints. In addition, GSH2 and IL-3 were found to be ectopically expressed in the leukemic cells, suggesting that expression of GSH2 and IL-3 was deregulated by the translocation. Besides the generation of fusion transcripts, deregulation of the expression of oncogenes could be a variant leukemogenic mechanism for translocations involving the 5' end of ETV6, especially for those translocations lacking functionally significant fusion transcripts.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME
Proteins RPR322Hu01 Recombinant GS Homeobox Protein 2 (GSX2) Customize
Antibodies PAR322Hu01 Polyclonal Antibody to GS Homeobox Protein 2 (GSX2) Customize
MAR322Hu21 Monoclonal Antibody to GS Homeobox Protein 2 (GSX2) Customize
Assay Kits SER322Hu ELISA Kit for GS Homeobox Protein 2 (GSX2) Customize
SCR322Hu CLIA Kit for GS Homeobox Protein 2 (GSX2) Customize
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME
Proteins RPR322Mu01 Recombinant GS Homeobox Protein 2 (GSX2) Customize
Antibodies PAR322Mu01 Polyclonal Antibody to GS Homeobox Protein 2 (GSX2) Customize
MAR322Mu21 Monoclonal Antibody to GS Homeobox Protein 2 (GSX2) Customize
Assay Kits SER322Mu ELISA Kit for GS Homeobox Protein 2 (GSX2) Customize
SCR322Mu CLIA Kit for GS Homeobox Protein 2 (GSX2) Customize
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME
Proteins RPR322Ra01 Recombinant GS Homeobox Protein 2 (GSX2) Customize
Antibodies PAR322Ra01 Polyclonal Antibody to GS Homeobox Protein 2 (GSX2) Customize
MAR322Ra21 Monoclonal Antibody to GS Homeobox Protein 2 (GSX2) Customize
Assay Kits SER322Ra ELISA Kit for GS Homeobox Protein 2 (GSX2) Customize
SCR322Ra CLIA Kit for GS Homeobox Protein 2 (GSX2) Customize